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It is stable in human gastric juice and is often studied in both oral and injectable research models

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These may include: Blood sugar abnormalities High blood pressure Headaches and nausea Hormonal imbalances Muscle damage Long-term misuse may increase the risk of blood clots, bone loss, and certain cancers

10.1016/j.neuropharm.2013.04.024 Neuropharmacology 16 BellantiF.MatteoM.RolloT.De RosarioF.GrecoP.VendemialeG.et al (2013)

BCG-trained M cause increased expression of H3K4me3 and H3K27ac at the promoter sites of genes essential for glycolysis (114), as well as decreased expression of H3K9me3 (161), resulting in changes in cellular metabolism (118)

Natural polymeric NPs including chitosan, gelatin, albumin, and alginate are commonly employed for topical skin administration and targeting skin melanoma